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Interestingly, administration of the l-theaninecaffeine combination was associated with a significant decrease in reactivity of CEN compared to placebo in a cluster that included the bilateral middle and superior frontal, paracingulate and precentral gyri and the left inferior frontal gyrus (p = 0.007)

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Subsequent increases occur every four weeks, moving to 7.5mg, 10mg, 12.5mg, and finally 15mg, which is the maximum approved dose for weight management